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Molecular Biology of Neurodegeneration
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Neurodegenerative disorders are one of the most important, unsolved health challenges of today's societies.
In the focus of our research activities is the molecular pathogenesis of Huntington's disease (HD), a monogenic, dominantly inherited, fatal neurodegenerative disorder.
We use a transgenic Drosophila model to investigate the disease, which is based on the neuron specific expression of the human huntingtin gene fragment responsible for HD.
This model enables us to analyze the molecular background, molecular pathomechanisms of the disease.
Our current research efforts are primarily focusing on the role of chromatin structure and protein clearance systems in Huntington's disease using genetics, molecular biology, transcriptomics and behavioral assays.
Furthermore, we collaborate with several research groups providing transcriptomic, genomic and functional genomic research solutions.
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Principal Investigator:
László Bodai, PhD.
associate professor
OrcID: 0000-0001-8411-626X
Publons: A-9764-2012
Scopus: 6506212056
ResearchGate
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Selected recent publications:
Dysregulated miRNA and mRNA Expression Affect Overlapping Pathways in a Huntington’s Disease Model.
Zsindely N, Nagy G, Siági F, Farkas A, Bodai L.
Int J Mol Sci. 2023. 24(15):11942 doi: 10.3390/ijms241511942.
Acetylation State of Lysine 14 of Histone H3.3 Affects Mutant Huntingtin Induced Pathogenesis.
Faragó A, Zsindely N, Farkas A, Neller A, Siági F, Szabó MR, Csont T, Bodai L.
Int J Mol Sci. 2022. 23(23):15173. doi: 10.3390/ijms232315173.
DNA Methylation in Huntington's Disease.
Zsindely N, Siági F, Bodai L.
Int J Mol Sci. 2021. 22(23):12736. doi: 10.3390/ijms222312736.
The histone replacement gene His4r is involved in heat stress induced chromatin rearrangement.
Faragó Anikó, Ürmösi Adél, Farkas Anita, Bodai László.
Sci Rep. 2021. 11: 4878. doi: 10.1038/s41598-021-84413-4.
Green tea infusion alleviates
neurodegeneration induced by mutant Huntingtin in
Drosophila.
Varga Júlia, Dér Nikolett Petra, Zsindely
Nóra, Bodai László
Nutr Neurosci. 2020. 23(3):183-189. doi: 10.1080/1028415X.2018.1484021.
Hat1 acetylates histone H4 and
modulates the transcriptional program in Drosophila
embryogenesis.
Varga Júlia, Korbai Szabina, Neller
Alexandra, Zsindely Nóra, Bodai
László.
Sci Rep. 2019. 9(1):17973. doi: 10.1038/s41598-019-54497-0.
Mutant huntingtin disturbs circadian
clock gene expression and sleep patterns in
Drosophila.
Faragó Anikó, Zsindely Nóra, Bodai
László.
Sci Rep. 2019. 9(1):7174. doi: 10.1038/10.1038/s41598-019-43612-w
Histone methylation in Huntington's
disease: are bivalent promoters the critical targets?
Zsindely Nóra, Bodai László
Neural Regen Res 2018. 13:1191-2 doi: 10.4103/1673-5374.235029
All publications on: PubMed
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