Protease Chatalysis and Stability

PI: Márta Kotormán, PhD. assistant professor

Preventing protein-conformational diseases that are damaging to the lives of millions of people worldwide can be more effective than treating them. There are many protein aggregation inhibiting compounds among the bioactive molecules of plants. The beneficial effect of these may be to stabilize the native structure of the proteins or to prevent fibrils formation. All protein can form fibrils under appropriate conditions. The inhibition of fibril formation is examined as a model protein using trypsin or alpha-chymotrypsin in ethanolic medium at pH 7.0. We use various red wines, teas, coffees, dietary supplements, spices and fruit juices as inhibitory agents.

All publications on: PubMed